Mayo River Vacations from $399

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The Latest Mayo River vacation packages

Price found within the past 48 hours. Click for updated prices.
Summit Street Inns

Summit Street Inns

3.5 out of 5
Price was $473, price is now $399 per person
$399
per person
Feb 6 - Feb 8
found 1 day ago
Roundtrip flight included
New York (NYC) to Greensboro (GSO)
9.8/10 Exceptional! (214 reviews)
Spacious room; shower was phenomenal; comfy beds; bathrobes were a nice addition; several extras that made it feel special

Reviewed on Dec 30, 2025

O.Henry Hotel

O.Henry Hotel

4 out of 5
Price was $766, price is now $566 per person
$566
per person
Feb 6 - Feb 9
found 24 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
9.8/10 Exceptional! (724 reviews)
Breakfast menu was limited.

Reviewed on Jan 2, 2026

Hotel Denim

Hotel Denim

3.5 out of 5
Price was $544, price is now $431 per person
$431
per person
Feb 12 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Greensboro (GSO)
9/10 Wonderful! (1,015 reviews)
Even though I didn’t check in until 9 pm and got a room on the 1st floor close to the lobby. I could hear the noises in the lobby. At 3 AM I was woken by loud banging - to me it sounded like maybe a physical altercation. I called the front desk and let the desk clerk know. The next morning I was going to shower before I checked out but there was no hair dryer in the room. I know I could have called the desk but that is a basic room item and should have already been in the room. I would not stay with you again Gayle Swope

Reviewed on Jan 2, 2026

Courtyard by Marriott Burlington

Courtyard by Marriott Burlington

3 out of 5
Price was $595, price is now $472 per person
$472
per person
Feb 12 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Greensboro (GSO)
8.6/10 Excellent! (474 reviews)
Our room had some age, as in carpet stains & blemishes. It was clean and staff was very friendly. Gone are the days to ask for something from housekeeping. They will ask you to come down to the front desk to get it.

Reviewed on Nov 9, 2025

Proximity Hotel

Proximity Hotel

4 out of 5
Price was $809, price is now $659 per person
$659
per person
Mar 5 - Mar 8
found 7 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Greensboro (GSO)
9.6/10 Exceptional! (879 reviews)
Room was spotless and staff was amazing. We'll definitely stay there again!

Reviewed on Dec 26, 2025

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Discover the most popular places to visit in Mayo River

The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Reynolds Homestead

You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas.

Reynolds Homestead

Mayo River Hotel Deals

The Lodge at Primland, Auberge Collection

The Lodge at Primland, Auberge Collection

5 out of 5
2000 Busted Rock Rd Meadows Of Dan VA
$428 nightly
The price is $481 total per night from Jan 29 to Jan 30
$481 total
Jan 29 - Jan 30
Total with taxes and fees
9/10 Wonderful! (25 reviews)
The resort is an experience. The staff were helpful and genuine.

Reviewed on Nov 9, 2025

The Lodge at Primland, Auberge Collection
Baymont by Wyndham Eden

Baymont by Wyndham Eden

2.5 out of 5
716 Linden Dr Eden NC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $84 total per night from Jan 9 to Jan 10
$84 total
Jan 9 - Jan 10
Total with taxes and fees
8.4/10 Very Good! (559 reviews)
room was clean. staff was helpful

Reviewed on Dec 28, 2025

Baymont by Wyndham Eden
Comfort Inn Martinsville

Comfort Inn Martinsville

3 out of 5
378 Commonwealth Blvd W Martinsville VA
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Jan 18 to Jan 19
$110 total
Jan 18 - Jan 19
Total with taxes and fees
6.6/10 (622 reviews)
Room was clean. Check in was seamless.

Reviewed on Dec 22, 2025

Comfort Inn Martinsville
See all 266 properties in Mayo River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo River Vacation Packages

Mayo River Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Piedmont Triad Intl. Airport (GSO)

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Frequently asked questions

How much does a Mayo River vacation package cost?
You'll find cheap prices from $399 on Expedia for your Mayo River getaway. However, a range of factors like the season, choice of hotel and length of stay will determine how much your vacation to Mayo River costs.
What are the cheapest months to go to Mayo River?
March, August and December are the best times to look for cheap Mayo River vacation packages. Choosing to travel in quieter periods means you'll typically find lower prices on flights and hotels.
How many days is enough for Mayo River?
Typically, a handful of days is enough to explore the top sights during your Mayo River vacation. However, if you prefer to have more time to chill out or go on day tours, consider extending your itinerary.
How to find the best Mayo River package deals?
Bagging a cheap Mayo River package deal is easy with Expedia. After you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can personalize your search by "Amenities," "Property type," "Popular locations" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Mayo River package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Mayo River vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll generally land a better deal than booking each component separately. And you'll still get the freedom to create a customized Mayo River vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Mayo River?
Secure incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mayo River adventure.
How to plan a trip to Mayo River?

  1. Choose when to travel: Check your schedule and pack your bags. Your favorite time of year and the type of activities available will also help you decide when to visit Mayo River.
  2. Calculate your budget: Ensure you have enough money to cover everything from transportation and meals to experiences and flights. Your accommodations will likely be the biggest expense during your trip to Mayo River.
  3. Use our trip planning tool to discover Mayo River: Research every part of your trip to Mayo River with this handy planner. Invite your family and friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Set the duration of your trip: Start by listing all the attractions you'd like to experience in Mayo River. Then, estimate how long you'll need at each, as well as any travel time.
  5. Bundle your bookings: With your travel dates in order, you can combine your hotels, car rental, flights and more into a customized Mayo River vacation package.
  6. Add on excursions and experiences: Have a look at our dedicated travel guide to find some exciting things to do in Mayo River. Book tickets or make reservations as soon as you can to save time and skip the hassle of looking for activities once you arrive.

Does Expedia offer Book Now, Pay Later Mayo River vacation packages?
Set off on your dream escape to Mayo River with our Book Now, Pay Later vacations. No need to save like crazy or wait until the next payday — we've teamed up with online lender Affirm to give you more financial flexibility. Our vacation packages with payment plans allow you to spread the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, you can easily stay on budget and snap up travel deals while they last.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.